Chloramphenicol therapy of typhoid fever.
نویسندگان
چکیده
In a prospective study we compared two different dosage regimens of IV chloramphenicol succinate (100 mg/kg/day and 75 mg/kg/day) in children with culture proven typhoid. Trough and peak blood samples, obtained at 48 hrs, were analysed for free chloramphenicol by high pressure liquid chromatography (HPLC). Although the mean trough (8.8 +/- 7.7 versus 5.4 +/- 2.6 mcg/ml) and peak (19.9 +/- 12.2 versus 15.4 +/- 6.1 mcg/ml) chloramphenicol concentrations were comparable in both groups, a significantly wider range was found in the group receiving 100 mg/kg/day. Potentially toxic levels (greater than 30 mcg/ml) developed in two patients with liver dysfunction. Chloramphenicol in a dosage of 75 mg/kg/day is adequate and safe for the treatment of paediatric typhoid.
منابع مشابه
کوندرودیسپلازی متافیزال معرفی دو بیمار مبتلا به نوع Schmid
Typhoid fever is an endemic disease in Iran and other developing countries. This disease has gradually become resistant to the first line of drugs, and because of this resistancy we have studied a new alternative drug (cefixime) on typhoid fever patients and compared it's effectiveness with chloramphenicol. For this purpose, by a randomized clinical trial in Emam Khomeini hospital between 1995-...
متن کاملManagement of Typhoid Fever and Bacterial Meningitis by Chloramphenicol in Infants and Children
Chloramphenicol inhibits protein synthesis in bacteria and is usually bacteriostatic but is bactericidal against Haemophilus influenzae, Streptococcus pneumoniae, and Neisseria meningitis. Chloramphenicol penetrates all body tissues well. The cerebrospinal fluid concentration averages 60% of the serum level, while brain levels are 9 times higher because of high lipid solubility of this drug. Ch...
متن کاملمقایسه اثر بخشی داروی سفیکسیم با کلرامفنیکل در درمان بیماران تیفوئیدی مراجعه کننده به بیمارستان امام خمینی از تیرماه 1377 لغایت شهریور 1379
Typhoid fever is an endemic disease in Iran and other developing countries. This disease has gradually become resistant to the first line of drugs, and because of this resistancy we have studied a new alternative drug (cefixime) on typhoid fever patients and compared it's effectiveness with chloramphenicol. For this purpose, by a randomized clinical trial in Emam Khomeini hospital between 1995-...
متن کاملChloramphenicol combined with ampicillin in treatment of typhoid.
Fifty out of 100 patients with typhoid fever, matched for age, stage of illness, and degree of fever, were treated with chloramphenicol and the other 50 were treated with chloramphenicol combined with ampicillin. The febrile period was shortened by up to 29% in patients treated with the combined drugs compared with those given only chloramphenicol. Moreover, no patient on combined therapy had a...
متن کاملSerum zinc, iron, and copper concentrations during typhoid fever in man: effect of chloramphenicol therapy.
In volunteers experimentally infected with Salmonella typhi, serum iron and zinc concentrations became significantly depressed and there was a concomitant rise in serum copper before the onset of overt clinical illness. However, after several days of fever and the initiation of chloramphenicol therapy, serum iron and zinc concentrations significantly increased. Additional studies--in volunteers...
متن کاملStudies on cortisone and antibiotics for prompt therapeutic control of typhoid fever and scrub typhus.
Prior to the use of chloramphenicol in the treatment of patients with typhoid fever the mortality rate in this disease was almost 10 per cent and approximately one-fourth of the deaths were attributable to the toxic-febrile state (1). Chloramphenicol has been shown to control the bacteriologic manifestations of typhoid fever within a matter of hours but the toxemia has responded more slowly to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- JPMA. The Journal of the Pakistan Medical Association
دوره 41 2 شماره
صفحات -
تاریخ انتشار 1991